please answer the questions and provide written work for how you did the calculation and explanations

please answer the questions and provide written work for how you did the calculation and explanations.

Problem 4: The elimination half-life of tobramycin was reported to be 2.15 hours and the Vd was reported to be 33.5% of body weight. Assume that the drug is given by intravenous bolus injection every 8 hours.

a. What is the dose for an 80kg individual if a average steady-state level of 2.5 mg/L is desired?

b. Explain what will be the consequence if patient develop kidney or hepatic dysfunction.

Problem 5: The manufacturer has suggested that in normal cases, tobramycin should be given at a rate of 1 mg/kg every 8 hours. With this dosage regimen for the same patient at problem 4,

a. What would be the plasma average steady state level?

 

please answer the questions and provide written work for how you did the calculation and explanations

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